I've used amquel dechlorinator, a basic fish dechlorinator and ammonia remover with frogs for years. I recently picked up a bottle of reptisafe to compare, actually. I'll be making a thread on it later. It is quite safe, but does not boast electrolytes and/or calcium supplementation in the water like reptisafe does. For the price difference and certain aspects of my experience with reptisafe, I think I will be continuing with amquel in the future.