I have never had eye problems following treatment, but I do allow the continuous spray version to sit out for a few minutes so some alcohol can evaporate. It is important that all parts of the frog come in contact with the solution so there is no way to avoid the eyes. I usually use an 8 oz deli cup and lid for treatment, I fill it halfway, put the frog in, and gently tilt it around so that the solution runs over the entire frog, then let them sit in it.