My frogs always pee on me when I handle them. Even my very old fire- bellied toads that are very used to being picked up. Its just a natural instinct to avoid getting eaten. My frogs are always scared when I first pick them up but calm down ( I think ) after they realize it's just me and will sit in my hand. Gray tree frogs are very smart but be patient with Paddy. It took me about 2-3 weeks to get my gray TF to be comfortable with me. Now he sits and looks out of his tank at me and sings loudly, and when I put my hand near him, sometimes he grabs on.