Hybridisation is a method of evolution, non african humans are about 4% neanderthal according to new evidence. The way I see it, it's adding to the variety of this world and amphibians are a declining group..

More philosphical than practical help, my opinions are essentially if you can without causing suffering, go for it, just get as much help as possible, and of course you'd have to be realistic is the choices for mixing.

Ever saw a Tigon? Liger? Half Zebra Horses? Mixed Cats and Dogs.. etc etc