Based on your description, your frog probably has bloat. There are two kins of bloating disease. Here is an explaination, you may have to consult a vet.
Sorry to hear about your frog. Bloated frogs seem to be very common these days. Xenopus (African clawed frogs) experience two kinds of "bloat".
1) "Hard" bloated frog appears all of a sudden at the surface of the water. If this is the case, you will need to quarantine yor frog. This condition is usually caused by an internal bacterial infection and in nearly all cases it is fatal. There is some success using a product called Maracyn along with a salt bath. Maracyn is a gram-positive antibiotic found in stores that sell tropical fish supplies. Your vet will be able to advise you on a treatment plan.
2) "Soft, squishy bloat", sometimes known as the "Michelin man syndrome" or hydrops in older amphibian literature, is caused by an excessive amount of fluid accumulation in the body and limbs. Untreated, this can cause liver and kidney damage. Although, frogs can live a long period of time with this condition, it will eventually lead to death. This condition is not associated with any particular pathogen, but it does occur with poor husbandry conditions. Since aquatic frogs live in water, their skin acts as an way for fluids to enter and exit the body (osmosis). When this process is interrupted, the frog begins to swell. The two leading causes of this swelling is poor water conditions and poor diet. Repto-Min is a perfect diet for your clawed frogs. ACFs are both predator and scavenger, so they do not require live foods like other frogs. I have been keeping clawed frogs for over 30 years and only feed Repto-Min. The only other problem could be the water. Make sure you use a good water conditioner, I recommend Stress-Coat. Keep the water clean and siphon any uneaten particles or waste. I would talk to the vet again about draining the fluid, the frog will probably recover without the additional stress. Also, continue the salt bath, ACFs are very salt tolerant and this would reduce the bloat.
Treatment: The easiest way to treat the frog is to put him in a plastic container (like Rubbermaid) about 3 gallons in size. Put a gallon of conditioned water with about a half-teaspoon of epsom salts. Water temperature should be about 72 degrees. Dissolve the salt before putting the frog in. Don't put anything else in the container. Punch some small holes in the lid for ventilation. Leave the frog in the bath for 1 hour each day until the bloat is clear. Replace fresh water and salts each day. If the bloat isn't cleared within 10 days, then there isn't much more you can do. Don't feed live food. I suggest Tetra's Repto-Min frog pellets.
Watch for any unusual skin discoloration which could be as sign of bacterial or fungal infection. Usually the salt bath will take care of this problem too.
I understand your frustration. Be patient and most likely things will go well for your frog.





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