I only bring it up because on a different forum (for Chameleons) there was a huge outrage about pet stores selling expired vitamins. I think the verdict was that expired calcium is OK but mulit vitamins is not. I do not know how accurate the responses were, thats why I hoped one of the experts on this forum could chime in... Chameleons are super fragile creatures so it may effect them more then frogs. Sorry I can not give you a definite answer...I don't want to tell you something that I am not 100% sure about myself.