I use Repashy Calcium Plus exclusively, and have since they released it many years ago. In my opinion, there's no substitute. Everything else is either inferior or not as sticky. I too find it annoying that it has to be replaced regularly but I also find it reassuring that my frogs and salamanders are getting the correct nutrients. The issue is mainly due to exposing the vitamins to the calcium and other mineral dusts - they hasten the breakdown of the other compounds in the presence of oxygen and water. What I do is I buy the smallest tub of Repashy (3 oz I think?) and I write the opening date on the lid with permanent marker. I throw any remnant away after about 6 months. I don't refrigerate it but I also don't keep it in a warm room. The main benefit you're getting from calcium plus is the calcium itself, and the calcium content won't change, even if the concentration of the organic compounds (vitamins, pigments, etc) in the dust decrease over time. So you could use it as just a calcium and mineral supplement indefinitely.