“Red leg” is not one specific disease in and off itself. Rather, it is a symptom of any number of different infections. Usually this results from poor husbandry leading to a systemic infection. Sometimes there are other underlying health issues and opportunistic infection sets in. It is always practical to seek veterinary guidance and obtain a proper diagnosis as treatment may vary. However, once the symptom is noticed the prognosis is generally poor. Proper husbandry and quarantine protocols are the best methods for lessening the risk on infections both primary and secondary. As far as “natural remedies” honey does have antimicrobial properties but this is not going to treat a systemic infection. Medications designed for fish are sometimes used but the dosage is designed to be diluted in parts per gallon. It is therefore impractical and potentially dangerous. The drugs are sometimes the same but must be administered in the correct dosage.