So, she's still holding the same - edema in her abdomen and muscle wasting in her extremities. Still eating and defecating normally.

She had a vet visit almost a month ago, and we ran through differentials. Parasites were brought up and she was treated, no change. MBD of course was talked about, especially since there can be a kind caused by malabsorbtion (I have a snake with this), but I had gone into active MBD protocol (replaced UVB and changed calcium to Rescuecal) a month prior just in case, no change. Diet was brought up, maybe meals were too large, switched that out to smaller items less frequently, no change. Doc did not see any physical signs of an infection.

Doc brought up that cancer is surprisingly common in older frogs. Given her symptoms and lack of response to other treatments, this is looking like the most likely scenario. I've dealt with cancer over a dozen times in cats (one of my ten year olds just got diagnosed with lymphoma a couple weeks ago), and with quite a few fish over the years. The muscle wasting, abdominal swelling, lack of response to supportive care - as soon as she said cancer it sadly clicked.

So long as Ine as hanging in there and does not seem to be in discomfort and is eating, we'll keep going. She seems okay for now, just not the spunky girl she's always been.