I'm not sure about the Septicemia because mine had renal ( kidney failure ) so that's what I did all my research on and treated her for so I'm not sure if it will return if its the first one. But if its kidney failure its just a losing battle. Mine was a pacman frog so it wasn't very active to start with but you could just tell by looking at her that she wasn't comfortable and she stopped moving completely and would bury herself and stay down unless I dug her up. So maybe if yours is still doing all the froggy things its supposed to it isn't kidney failure and you may be able to save your frog. If you feel the meds are bugging her or she they aren't working I would still ask your vet if the soak would be a better way to treat it.