Honestly, I don't know. The Tetracycline I used was in powder form, intended for fish. The use of human medicines and other products is mostly based on example, records of someone using it on a frog. I couldn't find any records of it being used on a frog. You could try checking with John Clare, frog forum's administrator to see if it's safe. I'm not saying it isn't safe, just that I don't know it is safe. I'll do some googling to see if I can find any more information.