
Originally Posted by
monster
I found this but couldn't find anything on Vitamins, hope this can help a bit.
I'm going to copy this answer directly from my Amphibian Medicine and Captive Husbandry textbook by Kevin M Wright (regarded as one of the best books in amphibian medicine/research)
"Horn frogs, Ceratophrys spp., are often noted to have subcutaneous edema with or without fluid reserve for this and other frogs, but often it is linked to a problem such as metabolic bone disease and concomitant hypocalcemia (presumably due to alteration of the lymph heart function), acute bacterial infection, renal failure, hepatic failure (low plasma protein), or exposure to water with low dissolved solutes (often suggested by low levels of plasma sodium and/or potassium and protein). Supportive care should include bathing the frog in electrolyte solutions such as amphibian ringer's solution along with treatment of the underlying etiology if known."
I'm now editing because I went and got my horned frog book by Phillipe de Vosgoli because I could have swore I had seen something in it about edema and vitamins and I was right, here is what it says.
Note that over supplementation of vitamin D3 is possible, it can lead to a certain type of MBD as well as cause edema, notably throat edema. All these problems are influenced by metabolism and can be exacerbated by not keeping frogs at the proper temperature range for activity and feeding. If you don't have the book its a great book and recommend it, this info is on page 26.