Colorado river toads are great toads. However, you need to take some precautions due to the highly toxic skin secretions. Always wear "hospital" gloves, plain and no latex. Keeping these frogs are illegal in some states. The skin toxins contain two substances that are classified as Schedule I drugs by the DEA at the federal level and is therefore illegal to buy, possess, and sell.
5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine)
5-HO-DMT, Bufotenin

Legal possession of these toads on the state level is not very clear.