There are several gene mutations in flies that can lead to lack of the ability to fly (some of these have other effects: lethality in homozygous state, causing selective sterility of males or females, lowered growth / production rates, etc.)
Vestigial is one type of "flightless".
There are vestigial winged fruit fly strains, but I am unaware of similarly mutated house flies.
Both the British and US flightless houseflies found/reported have a curly winged mutation (to the best of my knowledge).
James





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