The occasional large mouse isn't the problem, it's the large food at low temperature. Their bodies don't thermoregulate, so their metabolism is based completely on ambient temperature. If it isn't warm enough, they may not digest the food fast enough and it can rot in their stomach, or pass partly undigested into their intestines, where pieces of bone or anything sharp could cause tears.
The swelling around the leg does look like a possible edema, caused by the kidneys not flushing out water at the correct rate. Most often it is caused by kidney failure due to long term exposure to low temps. Sometimes correctable, but it will all be based on the frog and extent of damage. Bring the temps up to the levels outlined in the care sheet sticky at the top of the forum to stop or slow the disease.





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