Help!!! Something just happened to my frog, and I'm not sure if something is wrong or if he is dying :(

[DVirginiana]

So Blob is less than happy about all of this. I have never really handled him much before this because pacman frogs are burrowers and I usually leave him alone other than to clean his tank. Will he get used to being held? He is so wiggly and pees everywhere, but I can't avoid picking him up because I need to give him medicine. I feel so bad stressing him out

They don't ever get to where they particularly 'enjoy' being held, but they get used to it where it doesn't stress them out terribly. The best thing about animals without object permanence is they don't remember you were there once you're out of their sight though, so he probably doesn't stay that stressed for very long