No I can't say I noticed a difference, but Calcium w/D3 added is such an important supplement for them I just cant bring myself to use an all in one. That way I know that at least 4 times a week they are being offered the supplement. Now how many flies or crickets are still dusted by the time the frogs eat them who knows, but that is why I do it so often.

I do like Repashys Supervite (multivitamin) they claim to have a new/better way to deliver the vitamins which allow the frogs to absorb them, repcal apparently uses an older way that has been proven less effective recently.

The Calcium plus (which is basically a Calcium, Multivitamin, and Color enhancer w/a bit of Vit A) I use simply for the color enchancer properties, but didn't want to do just a day of trying to keep the frogs pretty.

I will say my frogs all seem healthy and happy. No unhappy comments in the comment box I leave outside of all the vivariums lol. No happy ones either, but rarely does anyone tell you they are happy. they just complain when they are unhappy.