Not sure exactly what is going on here with this frog. I would set up a hospital tank, as you have done and treat this as a bacterial infection. This frogs slime coat has been compromised, far as I can tell. You can use aquarium salt and an anti-bacterial fish medicine to treat this. 20G may be pushing it for 3 large females, they're messy and females are huge.
Can I get the exact numbers on your water chemistry? Ammonia, Nitrite, Nitrate, pH?





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