Brian, i'm with Paul on that, advising on something you have limited knowledge about may be very dangerous, some things require years of experience and still every single day you are finding something new. In exotic veterinary medicine even slightly wrong dosage or treatment protocol might end up very badly and it is very important to collect all history and to get as close as possible to correct diagnosis and therefore treatment. Talking of which, i just realized, i have never treated an aquatic frog hm... Lots to learn! But from fish tanks experience and my gut feeling - would it be wise to change water completely and to place each frog separately in quarantine with melafix and see how it will go instead of trying to figure out what is wrong with water? Just a though.