Quote Originally Posted by UncleChester View Post
It's highly dependent on the type of toad and the thing eating it. Some Garter snakes have developed a resistance to toad toxins and will happily chow down on them, while other snakes will need a trip to the ER and naturally avoid eating toads. It wouldn't be surprising if animals known for eating anything that fits down their mouths (like Bullfrogs) to have developed a resistance, but I don't know anything for certain here. The toad toxins vary across toad species as well.

I've always understood that a Bufo americanus was capable of doing in a cat or dog, but it's dependent on the size of the toad and cat/dog as well as how much is eaten. It's also not impossible that some people will have skin irritation when handling an American Toad, I never have but other people may react differently. I've never heard of any major health problems simply from touching an American toad. Good sense applies- don't let your cat or dog or child eat random animals (or plants) found outside and you never have to worry.

Here's a pile of details on various effects of toad toxins, including an LD50 table for cats for various toad toxins:

Erowid Psychoactive Toads Vault : Health #1

I'm not sure which is produced by the American Toad, and the article they seem to reference for the table isn't available freely but it looks interesting for toad toxin info: Pharmacology and toxicology of toad venom - Chen - 2006 - Journal of Pharmaceutical Sciences - Wiley Online Library

http://actor.epa.gov/actor/GenericCh...casrn=464-81-3 suggests the LD50 of American Toads Bufotoxin for cats is .3mg/kg
That is true, there are animals out there that the bufo toxin doesn't effect. I have also heard reports of people breaking out in rashes or getting sick when handling eastern spadefoot toads; but I think that is more of an allergic reaction. Got to love toads though.