Will this work?

[Namio]

Unfortunately, I doubt it.
It was difficult enough to get him to not smoke in our bedroom. That is where Duey, my ball python, stays.
Would moving her into the living room, and the frog into the bedroom be a better arrangement? Or should I just not get a frog?

Yea moving the animals to a smoke-free room/area would be a good idea. If he insists smoking indoor I would suggest getting an air purifier machine or something. Living in constant second-hand smoke is not good for you or him.

I'm not aware of any info on how long-term cigarette smoke exposure would affect amphibians but common sense tells me it can't be good. Amphibians have semi-permeable skin so they might be more sensitive to the smoke than us.