Well here's one thing i've learned... certain fish treatments/medications say on the bottle, 'can not be used with scaleless fish'. That is something to look out for when wanting to use with amphibians for sure.

Other than that, the only differences i've found is that Prime does not change PH because it is not acidic. ReptiSafe does lower PH, and also provides electrolytes and calcium to help replenish and rehydrate. hmmm

I just bought another bottle of each... will be switching between one and the other with each water change now and closely monitoring.

Major difference, and why I started this thread.

Large bottle of ReptiSafe (258ml) treats approx 258 gallons and costs about $10.

Medium bottle of Prime treats 2500 gallons and costs about $10. Yes, 10 times as much for the same price!