I posted the same question to Phillipe De Vosjoli, and heres what he had to say (hope he doesnt mind me quoting him)

"Ron,Since I wrote that booklet, I have seen so many attempts to commercialize horned frogs fail that I've concluded that a free market approach is the best. . The large scale breeders now offer a wife range of species and their selection makes them resistant to pressure from individuals who focus on a single species. Being successful to profitably breed frogs is difficult. If you have a market then definitely breed your frogs. One of the great obstacles to success is designing a system that allows large scale housing and rearing of froglets to reduce loss from cannibalism without it being so labor intensive that it becomes non profitable.

C. cornuta to my knowledge has not been bred to an F2 generation but one individual who focuses on this species may have. C. cornuta needs to be established in herpetoculture or it will one day no longer be available. Long generation time of about 3 years is one of the obstacles.
Ornate horned frogs should be bred as well as Budgett's frogs. In the case of all of these, introducing new blood from imports is a good idea (both Chacoan and Budgetts are imported once or twice a year, usually in fall/winter from Paraguay).

Hope this answers you questions.

Best,

Philippe"