i dont have red eyes but have two whites. i used to take mine out and completely gut the tank but now i just spot clean, they are in a large tank so its easy enough to clean whilst their asleep. when i did take them out i used to wear latex gloves and like u transfer them to a container but i found that it was stressing them out too much. sometimes now the frogs will jump on my hands when i go to change water etc which i dont really see a problem in. i think so long as ur not just gettin them out to handle on purpose there shouldnt b a problem but make sure that u moving them isnt stressing them out