I don't see why every now and again handling would be harmful. I would just make sure to wash your hands thoroughly before and after handling. A frog's skin is very sensitive. I hold my frogs every now and again. I had to pick up Froggy for his photos to move him to my make-shift light box. I was also feeding one of my grey tree frogs and s/he was sitting on top of my tongs and I picked him/her up and s/he started climbing up my hand. lol. Just as long as it is not every day I think they should be just fine.