This sounds like just normal behavior from a frog that is trying to acclimate to his new home. Try not to handle him at all, if you do for brief amounts of time until he gets more used to your routine. As long as you use powder-free Nitrile gloves he'll be fine, I would just be careful your gloves aren't stretching his sensitive skin. Some people are allergic to latex so I wouldn't want to risk seeing if a frog had an allergic reaction to it too, so to be safe use Nitrile. Alternative to people who are allergic to latex. He doesn't go into a defense mechanism when you handle him with your bare hands? Only with the gloves? Clarify please.